![]() ![]() Further, we provide a review of 27 paediatric (≤19 years median age 16) cases of severe COVID-19 outcomes, drawn from media sources published between March and September 2020, in which we identify possible evidence of a ‘hyper brain, hyper body’ response to infection. Drawing on a select review of published research and case reports, we discuss immune dysregulation in paediatric patients with a high IQ, including post-infection cytokine expression in the myocardium. As information and evidence about SARS-CoV-2 infection continue to expand, our hypothesis suggests adding a potentially intriguing piece to the pandemic puzzle for further investigation. MIS-C is associated with a higher risk of COVID-19 morbidity and death, even in otherwise healthy children. ![]() We identify studies of autoimmunity to support our hypothesis that a high intelligence quotient (IQ) may put children at increased risk for severe COVID-19 sequelae especially those whose viral load is high and/or who develop multisystem inflammatory syndrome in children (MIS-C). The body’s innate and acquired immune systems are critical in responses to a wide spectrum of assaults, including SARS-CoV-2 infection. ![]()
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